The titration schedule is as follows: 1-4 weeks : The dosage starts at 1 mg once weekly for 4 weeks
In this case, Ozempic could be prescribed for weight loss instead of type 2 diabetes
Triple Agonists (GLP-1/GIP/Glucagon) Titration and Tapering Algorithms At a glance Prototype agent / retatrutide (LY3437943), subcutaneous weekly injection Phase 2 peak weight loss / 24.2% at 48 weeks (12 mg cohort, N=338 total trial) Titration duration / 24 weeks across 4 dose steps before reaching maintenance Starting dose / 2 mg subcutaneous once weekly for weeks 1 to 4 Maintenance dose range / 8 mg or 12 mg once weekly depending on tolerability Primary targets / obesity, MASLD, type 2 diabetes, metabolic syndrome GI adverse events / nausea in 53 to 65% of participants at higher dose steps Taper recommendation / dose reduction over 8 to 12 weeks when discontinuing FDA status / Phase 3 (TRIUMPH program) ongoing as of early 2025
Non-invasive and quick : A simple procedure with minimal discomfort and no downtime required
In recent years, GLP-1 medications such as Ozempic , Wegovy , and Saxenda have moved rapidly into the public spotlight, reshaping conversations around weight management