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Notably, while AP/NTS neurons express GLP-1Rs [3, 47], inhibiting GLP-1R-expressing AP neurons does not prevent the appetite-suppressing effects of endogenously released GLP-1 [39], likely because of low amounts of GLP-1 reaching these neurons due to rapid GLP-1 degradation by the enzyme dipeptidylpeptidase IV (DPPIV) [48]
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Key studies Ipamorelin, the first selective growth hormone secretagogue (1998) Raun K, Hansen BS, Johansen NL, Thgersen H, Madsen K, Ankersen M, Andersen PH European Journal of Endocrinology 139(5):552561 Participants Rats (Sprague-Dawley), pigs, dogs
Note: While the molecule is identical, the FDA-approved indications, the pen delivery systems, and the maximum available doses differ between these two brands
These include the Tirzepatide injection pen or syringe, alcohol swabs, a sharps disposal container, and a clean tissue or cotton ball
