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The hGM experiments were performed using the facilities of the National Laboratory Animal Center, National Applied Research Laboratories, Taiwan, and were approved by the Institutional Animal Care and Use Committee (IACUC2017O04)

Combined evaluation, where performed, is interpreted through discrete molecular endpoints rather than organism-level functional claims

However, any combination approach should be undertaken with medical supervision and careful monitoring of cumulative effects

For starters, estrogens activate an enzyme known as tryptophan hydroxylase, which is key to serotonin synthesis

Nat Chem Biol (2019) 15:113747