Using structure-based analyses and cell models, including patient fibroblasts, of this variant, we found that the missense variant destabilized a critical loop, which disrupted the active site and caused a substantial loss of enzymatic function
Smith explained that while many prescriptions are for diabetes, the same companies have rebranded products specifically for weight loss, contributing to the demand
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For many patients, especially those with type 2 diabetes, obesity, or weight-related health concerns, these medications can be powerful tools when prescribed and monitored appropriately
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