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As with many things, the individual will sort out the most effective method for them
Studies show both daily and weekly shots can work, depending on the patients situation
SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024
SUMMARY Intramuscular injections are considered the gold standard when it comes to vitamin B12 supplements
If youre dealing with fatigue, low energy, or uncertainty about your nutrient status, blood work may help you make a more informed choice
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