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Key Takeaways GLP-1 (glucagon-like peptide-1) is produced in your gut after eating and signals your brain that you're full
The designation of certain GLP-1s as weight-loss agentsstarting with Wegovy in June 2021 and followed by Zepbound in November 2023made these drugs available to a new, huge swath of people
It improves insulin sensitivity, which shifts your body metabolic machinery toward fat utilization rather than fat storage
Key takeaway: Nausea is the most common side effect when starting GLP-1 medications, but it is typically temporary and manageable
This is a well-characterized physiological response to caloric deficit and weight loss, not a drug-specific anomaly
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