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Fewer sebaceous glands, lower baseline collagen turnover

Delayed Treatment: Vitamin B12 deficiency left untreated for longer than 3 months may cause permanent spinal cord and nerve damage

Due to the compounds plasma half-life of approximately 3.86.9 hours [5] , twice-daily (BID) dosing may provide more sustained NNMT inhibition

Response-Based Approach: Treatment duration is individualized based on objective measurements including body composition analysis (DEXA scan, bioimpedance), waist circumference, metabolic markers, and subjective response