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Important safety considerations include: Increased hypoglycaemia risk when used with insulin or sulfonylureas (dose adjustments of these medications may be needed) Potential worsening of diabetic retinopathy with rapid improvement in blood glucose control, particularly with semaglutide Need for monitoring in patients with pre-existing retinopathy The MHRA continues to monitor the safety profile of these agents

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Combining these two medications would likely increase the risk of serious side effects like severe nausea, vomiting, pancreatitis, and dangerously low blood sugar without providing any additional benefits

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