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Reduced food intake can lower nutrient intake, but B12 need should be based on diet, symptoms, metformin use, surgery, gastrointestinal disease, and laboratory assessment rather than the GLP-1 medication alone

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In contrast to rAmy, Cagri primarily engages the CTR in a bypass conformation, equivalent to that observed when bound to AMYRs, with 85% of particles in the final particle stack stabilised in this conformation (Fig

Because MOTS-c enhances insulin-independent glucose uptake, patients with type 1 diabetes or those using exogenous insulin should be monitored carefully to prevent hypoglycemia, though this theoretical risk has not materialized in clinical reports to date

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