glp-1 for weight loss without diabetes is driven mainly by fat loss, not muscle loss How Do GLP-1s Work? Benefits

As other drug companies started to see the potential of these peptides, they started tweaking them like chemists playing with Legos

Jahrestagung der American Academy of Ophthalmology wurden zwei neue Studien zur Einnahme von GLP-1-Medikamenten im Zusammenhang mit Augenerkrankungen vorgestellt mit gemischten Ergebnissen

*Cell Metabolism*, 27(5), 1067-1080

While it remains to be established if specifically inhibiting LC-NE neurons has a similar effect, these findings suggest that systemic GLP-1R agonists activate presynaptic GLP-1Rs on glutamatergic terminals synapsing onto LC-NE neurons, leading to their activation and suppression of food intake

See the FDA update and the MoCRA overview