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The maximum maintenance dose is 4.5 milligrams weekly

Angiotensin III (Arg-Val-Tyr-Ile-His-Pro-Phe) binds at the AT 1 but primarily at the AT 2 receptor subtype and modulates cell proliferation, cell differentiation, and apoptosis

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The smaller cohort participants were matched to their nearest demographic neighbor before analysis to improve comparisons between cases and controls