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In contrast, induction of ER stress via central administration of thapsigargin completely abolished the RYGB-mediated improvement in leptin sensitivity, without affecting control animals, highlighting ER stress as a key regulatory factor in the beneficial effects of RYGB on hypothalamic leptin signaling [97]
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The closer your doses are spaced, the higher the peak drug concentration, which can intensify the gastric emptying delay that causes nausea
