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Participants taking the highest dose of retatrutide saw, on average, the following health improvements: these average reductions in cardiovascular disease risk factors: 37 percent reduction in triglycerides, or fats in the blood 16.5 percent reduction in non-HDL bad cholesterol 9.3 mmHg reduction in systolic blood pressure, the pressure in the arteries when the heart beats 7.5-inch reduction in waist circumference 51.2 percent reduction in high-sensitivity C-reactive protein, a measurement of inflammation in the body Side Effects Led More Than 1 in 10 Participants to Drop Out Side-effect rates differed between the two trials

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doi: 10.3389/fphar.2022.856111 Received 16 January 2022 Accepted 15 February 2022 Published 08 March 2022 Volume 13 - 2022 Edited by Giuseppe Paolisso, University of Campania Luigi Vanvitelli, Italy Reviewed by Stefano Ciardullo, University of Milano Bicocca, Italy Maria Rosaria Rizzo, University of Campania Luigi Vanvitelli, Italy Updates Copyright 2022 Pahud de Mortanges, Sinaci, Salvador, Bally, Muka, Wilhelm and Bano