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Within seconds to minutes, your body releases: Histamine: Causes blood vessel dilation, increased mucus production, and itching Prostaglandins: Contribute to inflammation in airways Leukotrienes: Up to 10 times more potent than histamine at causing airway constriction Cytokines: Signal other immune cells to join the response Tryptase: An enzyme that promotes inflammation This is why blocking just one pathwaylike antihistamines dooften isn't enough

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