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We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs

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When gut bacteria become imbalanced, a condition called dysbiosis, it can contribute to various digestive issues including acid reflux

Pathway analysis between acute and R indicated alteration in 36 pathways as indicated in Supplementary Figure 7

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