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10.1093/toxsci/kfr183 Toxicol
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76 For instance, AARS1 functions as an intracellular lactate sensor, directly binding lactate to form lactate-AMP, and mediates lactylation of K120/139 on p53 within its DNA-binding domain (DBD), which prevents the binding of p53 to DNA containing p53 response elements (p53RE-DNA) and subsequent p53 liquidliquid phase separation (LLPS)
In this study, our genetic screening of the previously constructed hairpin RNA-based Arabidopsis library 19 identified a glutathione (GSH)-deficient mutant that highly accumulated Glu, the previously defined molecule crucial for activation of plant defense, but disharmoniously exhibited attenuation of defense signaling events
