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Its core feature is that intermittent access induces stable, high-level voluntary alcohol intake and preference in animals, closely mimicking human intermittent heavy drinking behavior observed clinically (Figure 1)

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Figure 1 4 Overview of the GLP-1 mechanism GLP-1 is an incretin hormone composed of 3031 amino acids, produced by post-translational processing of proglucagon and secreted by intestinal L-cells in response to nutritional and inflammatory stimuli, as well as by neurons in the brainstem