Athletes who maintain adequate glutathione levels consistently report better immune resilience through their hardest training blocks and race seasons
However, pediatric obesity differs substantially from adult obesity: ongoing growth, nutritional requirements, and psychosocial sensitivity raise concerns regarding potential effects on bone accretion, linear growth, and behavioral adaptation [130]
Am J Cancer Res 7(5):10161036 Franceschi C, Garagnani P, Morsiani C, Conte M, Santoro A, Grignolio A, Monti D, Capri M, Salvioli S (2018) The continuum of aging and age-related diseases: common mechanisms but different rates
Regulatory agencies increasingly recognize the value of surrogate endpoints, adaptive trial designs, and biomarker-driven patient stratification, particularly in areas of high unmet need
Epileptic seizures in the rat model of kainic acid-induced epilepsy have been shown to lead to reductions in the hippocampus of the most abundant phospholipid species that contain polyunsaturated fatty acyl chains [114]