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doi: 10.1056/NEJMoa2032183 20 FoxCKAuerbachPBarrientos-PrezMGiesIHalePMMarcusCet al
Where most therapeutic peptides degrade within minutes under simulated gastric or intestinal conditions, BPC-157 retains its integrity in human gastric juice for more than 24 hours, tolerates a wide pH range, and resists multiple proteolytic enzymes including pepsin and trypsin
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Key findings relevant to nausea included: Nausea was most prevalent during the dose-escalation phase and tended to diminish over time as participants adapted to the medication Higher doses were associated with higher rates of nausea and vomiting The majority of gastrointestinal events were transient and self-limiting Discontinuation due to gastrointestinal side effects occurred in a small but notable proportion of participants, particularly in higher-dose groups It should be noted that the weight-loss outcomes described above are from a Phase 2 trial and cannot be directly compared with those of licensed medicines without head-to-head data
