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These findings suggest that semaglutide may improve therapeutic strategies, reduce unnecessary screenings, and broaden its clinical applications, the authors write in Semaglutide Reprograms Macrophages via the GLP-1R/ PPARG/ACSL1 Pathway to Suppress Papillary Thyroid Carcinoma Growth . If validated in human trials, this research could fundamentally change care for millions of patients, moving semaglutide from a perceived risk to a potential protective asset in thyroid health

Discussion Due to the central roles exerted by the three metabolically related peptide hormone receptors (GIPR, GLP-1R and GCGR) in the management of T2DM and obesity, the concept of combinatorial agonism or polypharmacology to synergize metabolic actions and maximize therapeutic benefits has been explored in the past decade with remarkable preclinical and clinical achievements