In HT, the thyroid gland is gradually destroyed resulting in reduced production of thyroid hormones and triggering symptoms that include fatigue, weight gain, constipation, increased sensitivity to cold, dry skin, depression, muscle aches and reduced exercise tolerance ( 5 )
GS-6791 is a potent, selective, oral IRAK4 degrader designed to block inflammatory responses downstream of toll-like receptors and the pro-inflammatory IL1 cytokine family of receptors
LIR was also shown to cross the BBB following intraperitoneal administration at 25 and 250 nmol/kg, while no measurable increase in brain levels was detectable at the lowest tested dose, 30 min post-injection, nor at a later time point (3 h), even with the highest dose suggesting that LIRs brain penetration is both dose- and time-dependent (Hunter and Hlscher, 2012)
High-resolution longitudinal sleep data can reveal these differences and enables a personalized patient journey - adjusting dosing, timing, behavioral guidance, and follow-up based on how each individual actually sleeps as their physiology adapts
& Pearce, S