In a 4-week controlled trial of VYVANSE in pediatric patients ages 13 to 17 years, mean weight loss from baseline to endpoint was -2.7, -4.3, and -4.8 lbs., respectively, for patients receiving 30 mg, 50 mg, and 70 mg of VYVANSE, compared to a 2.0 pound weight gain for patients receiving placebo
The global sensitivity analysis suggests that the comproportionation reaction, R 5 , is not pivotal for the model OCR output, given that its parameters, k p5 and k m5 , are the two least sensitive parameters for both main and total interactions
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Note that trial durations differ and head-to-head comparisons are not yet available
If a dose is missed, the FDA label provides clear guidance: if fewer than four days have passed since the missed dose, inject as soon as possible and resume the regular weekly schedule