Afternoon energy crashes, sleep disruption (particularly 1-4 am waking), salt cravings, decreased stress tolerance, and postural blood pressure changes point toward needing a cortisol detox
Several GLP-1 medications are available, including: Mounjaro (tirzepatide) Ozempic (semaglutide) Rybelsus (oral semaglutide) Wegovy (semaglutide) Zepbound (tirzepatide) Ozempic, Rybelsus, and Wegovy are traditional GLP-1 agonists, which means they primarily activate GLP-1 receptors
Table 1 Baseline characteristics and laboratory outcomes for patients in the preceding cycle before and after PSM
Dual-Agonist Comparisons Tirzepatide (found in medications like Mounjaro) targets two receptors: GLP-1 and GIP
Liraglutide also has an FDA-approved obesity indication (Saxenda, 8.0% weight loss in SCALE), proven cardiovascular benefit (LEADER, 13% MACE reduction), and once-daily dosing without microsphere-related injection site reactions