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It explains why folate supplementation (particularly with 5-MTHF rather than folic acid in T/T individuals) improves endothelial function and reduces arterial stiffness in published clinical trials effects that operate partly through homocysteine lowering and partly through BH4 recycling restoration and improved eNOS coupling efficiency
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This hinted at what higher doses might do for obesity (discussed soon)
In contrast, there are no prior weight loss requirements to start using tirzepatide
That said, all of the studies have the same message: currently there is not enough evidence to prove that GLP-1 medications increase the risk of depression or suicidality
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