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Included as a reagent specification reference, not as clinical evidence

Copper also contributes to enzymes involved in connective tissue formation, antioxidant protection, pigmentation, and tissue maintenance

Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

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It has been estimated that about 90% of vegetarians and vegans may suffer such a deficiency