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Given that type 2 diabetes itself is a risk factor for nonarteritic anterior ischemic optic neuropathy [which constitutes approximately 75% of ischemic optic neuropathy cases] the potential for GLP-1 receptor agonists to further augment this risk has relevant implications for clinical decision making.
Although its not yet confirmed if this risk applies to humans, individuals with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 should avoid using tirzepatide
Layering both can slow digestion more than either one alone
