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Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )
For example, PLP is required for the synthesis of neurotransmitters such as GABA and serotonin, for heme biosynthesis (through -amino levulinate synthase in red blood cell production), and for amino acid transformations
Blood needs vessels
And thats even among people who I would say are relatively balanced diet individuals
Rare side effects: itching, exanthema, chills, fever, hot flushes, nausea, dizziness, and very rarely anaphylaxis
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