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The weight-loss results continued to the 48-week endpoint, with the 12 mg retatrutide group achieving a mean weight reduction of -24.2%, while the placebo group only saw a -2.1% change
Pericytes regulate angiogenesis, playing a pivotal role in modulating gene expression of endothelial cells and in controlling astrocyte polarization (Armulik et al., 2010)
Researchers also identified a dose response, meaning that the longer the patients took a GLP-1, the more likely they were to develop the condition
Gastrointestinal Effects The most frequent adverse effects of GLP-1RAs are gastrointestinal, including nausea, vomiting, diarrhoea and a sensation of early satiety