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Unexpected responses may indicate degradation products with different biological activities

Samaraweera, A

Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice

Preclinical studies suggest ALA may help defend neurons against oxidative stress, support synaptic function, and maintain healthy levels of glutathione, a critical antioxidant in brain cells.12 25 Importantly, ALA can cross the blood-brain barrier, making it a promising candidate for addressing conditions where oxidative stress or mitochondrial dysfunction play a role

Data from in vivo studies show that its selective accumulation in tumors can locally raise the temperature of tumors under near-infrared illumination, thus leading to the induction of effective photothermal tumor ablation for selective treatment (234)