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When will drugs like retatrutide, CagriSema, and orforglipron be available
Discontinuation rate: Only 1-2% stop during this period Psychological state: Highly motivated, visible results drive continued adherence Key achievement: Halfway to goal with strong momentum Weeks 25-36: The Steady State Phase (12mg Maintenance) Starting Weight Week 25: ~182 pounds | Expected Weight Week 36: 174-178 pounds | Net Loss This Period: 4-8 pounds | Total Loss: 42-46 pounds Whats Happening Physiologically Metabolic adaptation intensifies
doi: 10.1016/j.cell.2011.06.034 28
The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )
In ATTAIN-1 , the highest dose of orforglipron (36 mg daily) produced average weight loss of 12.4% (27.3 pounds) at 72 weeks
