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Pryor et al., 2019
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demonstrated that acetaminophen-induced liver injury is characterized by the recruitment of neutrophils that express TRAIL, which can trigger apoptosis in hepatocytes via the upregulation of the TRAIL receptor DR5
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2 For example, hepatotoxicity of acetaminophen is caused by the production of a highly reactive intermediate oxygen metabolite (N-acetyl- p -benzoquinoneimine)
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