(03:43): So you'd have efficient lowering of glucose through a dual mechanism with increasing insulin, lowering glucagon, and then it was safe because there wasn't this hypoglycemia you get from insulin
The hormone responses, however, were not as pronounced as seen in the perfused rat small intestine, suggesting that l-valine is not a powerful stimulator of gut hormone release from the distal part of the intestine
In fact, by improving blood glucose control, tirzepatide may reduce excessive urination in people with previously poorly controlled diabetes
Using medication slightly past expiration is probably safe but may be less effective due to degradation
Considering these preclinical studies, an ASO directed at PNPLA3, called ION839 (AZD 2693), is currently in phase I clinical investigation in patients with MASH carrying the I148M risk alleles of PNPLA3 (NCT04483947)