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Conversely, symptoms of hyperthyroidismsuch as anxiety, tremor, palpitations, heat intolerance, or diarrheawarrant evaluation, as they might indicate excessive thyroid hormone replacement

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In the last decade, studies on the condition of BBB in neurodegenerative diseases, including ALS, have demonstrated the presence of vascular disruption, a condition that could theoretically favour the entry of drugs into brain regions affected by neurodegeneration

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