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This binding triggers cells to open glucose transporters, essentially unlocking the door that lets blood sugar enter cells for energy
G.PhilippovP
Like SGLT-2 inhibitors, GLP-1 receptor agonists do not increase the risk of hypoglycemia severe enough to require treatment, but their use can cause gastrointestinal symptoms (NNH = 18
Once the GLP-1 hype is over, could natural alternatives take the lead
But even as far back as 1995, as Knudsens team was screening some of their early designs in mice, they saw that in addition to increasing insulin secretion, GLP-1 agonists made them eat less
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