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L.GarciaA.IzquierdoI.Mello-CarpesP
They use the same active peptide
Reduction in visceral and subcutaneous body fat
Reassess total daily insulin dose at 12 weeks on maintenance semaglutide Many patients reduce insulin by 40 to 60% total Some patients discontinue insulin if A1C is at goal (typically below 7%) and glucose is stable Recheck A1C at 3 months to confirm glycemic control Hypoglycemia response: If glucose drops below 54 mg/dL (severe hypoglycemia threshold), treat immediately with 15 grams fast-acting carbohydrate, recheck in 15 minutes, and contact your provider the same day to discuss further insulin reduction
Standard FDA-approved dosing escalation The FDA-approved tirzepatide dosing schedule, used in the SURMOUNT and SURPASS clinical trials, follows this pattern: Weeks 1 to 4: 2.5 mg once weekly (starting dose) Weeks 5 to 8: 5 mg once weekly Weeks 9 to 12: 7.5 mg once weekly (optional increase) Weeks 13 to 16: 10 mg once weekly (optional increase) Weeks 17 to 20: 12.5 mg once weekly (optional increase) Week 21 and beyond: 15 mg once weekly (maximum dose) Each dose increase happens after a minimum of four weeks at the current dose
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