Since its discovery in the periphery, the presence of PPG, GLP-1 and its receptor GLP-1R has also been reported in the central nervous system
Safety considerations Research peptides aren't FDA-approved for human use
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Converging Pathways: Metabolism, Inflammation, and Aging Under GLP-1 Modulation When viewed in isolation, the effects of GLP-1s on metabolism, cardiovascular outcomes, kidney function, liver health, and cognition are impressive
This is actually one argument in favor of microdosing , where gastrointestinal effects are minimized while anti-inflammatory receptor activation may still occur