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The metabolic impact of increased muscle mass compounds over time

This may also be due to the autoimmune attack on the parietal cells of the stomach in pernicious anemia

If tolerance is good and no adverse effects occur, increase to 75mg daily, often split into two doses of approximately 37.5mg each

NICE guidelines recommend evidence-based weight management through dietary modification (600 kcal/day deficit), 150300 minutes weekly moderate-intensity physical activity, and behavioural change strategies

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