Most GI events were classified as mild to moderate and occurred during the dose-escalation phase, consistent with the pattern seen across the GLP-1 receptor agonist class [4]
In mice, activation of this receptor has been associated with CCK secretion
3 Other metabolic imbalances increase the likelihood of treatment resistance by fourfold, thus emphasizing the need for personalized and metabolically informed treatment strategies
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To further confirm the effect of GLP-1R on central sensitization of CM, we measured alterations in CGRP expression in different drug-treated groups