surmount-1 tirzepatide obesity nejm 2022 weight loss percent For patients with #obesity, semaglutide, a glucagon-like peptide-1 receptor agonist, is approved for management as a once-weekly subcutaneous injection. In a previous trial, oral semaglutide at a dose of 50 mg NEJM on X: "Original Article:

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Administered as a once-weekly subcutaneous injection, it works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, and slows gastric emptying

The mean duration of type 2 diabetes mellitus was 8.6 years, and the mean BMI was 34 kg/m2

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A patient should not cease using the medication before consulting a doctor, as some conditions can deteriorate if one stops using it