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These contaminants stimulate host cells, including gingival macrophages and fibroblasts, leading to inflammation in periodontal tissue and alveolar bone resorption (Xu et al., 2020
This finding should be viewed in the wider context of the existing premise that high plasma cystine is a marker of oxidative stress: studies have linked high cystine and low rGSH to multiple adverse outcomes, including CVD pathogenesis (Go and Jones 2011), renal disease progression (Rodrigues et al
10.1507/endocrj.EJ12-0158 81
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And because most TRT and HRT patients only need in-person visits a handful of times per year, "closer" translates to actually consistent follow-up which is what makes optimization work
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