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While some users report enhanced local effects, the evidence for superiority over subcutaneous administration remains unclear, and complications including nerve irritation present greater concern

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Serotonin-expression evidence came from cultured rat cells

[9] Concomitant administration of large calcium supplements, thiazide diuretics, or aluminium-containing phosphate binders can potentiate vitamin D-mediated increases in serum calcium or phosphate, demanding periodic laboratory monitoring and dosage adjustments to avert nephrolithiasis or ectopic calcification