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Basal autophagy as a determinant of cardiomyocyte integrity and longevity In the absence of effective autophagy, cellular waste and misfolded proteins accumulate, generating proteotoxic stress, structural disorganization, and organelle dysfunction
Functional genomics For instance, CRISPR screens in the PINK1-Parkin mitophagy pathway have identified novel cofactors and signaling partners, expanding our understanding of mitochondrial quality control and offering promising therapeutic entry points in disorders such as Parkinsons disease
Convenient, with the most consistent (if modest) trial support, though absorption is debated and results are slower