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PINK1-parkin-mediated mitophagy protects mitochondrial integrity and prevents metabolic stress-induced endothelial injury
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Guo Z, Gao Y, Yuan X, Yuan M, Huang L, Wang S, et al
How Nasal Delivery Bypasses the Blood-Brain Barrier Through nasal inhalation, therapeutic compounds can reach the brain in minutes without passing through the bloodstream first
Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)
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