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In healthy individuals, GLP-1 is released after food consumption, particularly in response to proteins and fats, signaling satiety and stimulating insulin secretion
Individuals with autosomal recessive familial hyperinsulinism, caused by mutations in either ABCC8 or KCNJ11 (FHI-KATP), tend to be large for gestational age and usually present with severe refractory hypoglycemia in the first 48 hours of life
Some studies have found that these side effects are most common during the first eight to 12 weeks of treatment
Evaluation for other etiologies (fibroids, polyps, thyroid dysfunction, perimenopause) is warranted
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