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The combination limited and variable BBB transport plus rapid plasma degradation means peripherally administered DSIP delivers a brief and structurally heterogeneous exposure to the central nervous system, complicating dose-response interpretation in any whole-animal experiment
These likely stem from fluctuations in hormones and brain chemistry
In preclinical models, BPC-157 is studied using endpoints that include fibroblast-associated signaling markers, ECM-related gene/protein expression panels, nitric oxidelinked pathway activity, and growth factor receptor expression profiles
doi: 10.1097/GOX.0000000000002843
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