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Nowadays, FOXO4-DRI studies are focused on the following aspects: osteoarthritis (senescent chondrocyte clearance), metabolic dysfunction (insulin resistance and obesity-associated senescence), neurodegeneration (eliminating senescent brain cells), and fibrotic diseases (idiopathic pulmonary and liver fibrosis)

This suggests that convenience of dosing does not fully offset tolerability challenges ( Table 1 offer a comparison between the oral based GLP-1 agents

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