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There may be many reasons for this, including the foods you eat or other health issues, such as autoimmune diseases, that you live with

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Allergic reactions to b12 formulations True allergy to b12 itself remains extremely rare

Reconstitute with sterile bacteriostatic water or sterile saline at neutral pH so all four peptides dissolve in the same step

It's not all hype many people do feel a real difference