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Peak plasma concentrations in humans of dulaglutide were reported as 114 ng/ml (about 2 nM, Geiser et al
The peptide's resistance to dipeptidyl peptidase-IV (DPP-IV) proteolysis is achieved through substitution of -methyl-Phe at position 2, which blocks the cleavage of the Tyr1Ala2 bond that normally inactivates native incretins within minutes of secretion
2015;166(6):509-528.e1
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5 Things to Know About GLP-1s and Addiction
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