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Concurrent metformin use is well represented in diabetes trials, which often added tirzepatide on top of metformin
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Thanks are also extended to Sabine Bielfeldt, Isabelle Guillemin and Khadra Benmedjahed (for their help in conducting the interviews in France and Germany)
If SAM pools remain elevated due to reduced NNMT activity, downstream methylation pathways could theoretically be affected
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