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People taking tirzepatide often lose a lot of weight, though the exact amount depends on the dose
A fashion retailer with $1 billion in annual sales could lose up to $20 million in margin and an additional $20 million in unrealized sales from size curve inaccuracy
GLP-1s and Existing Underactive Thyroid (Hypothyroidism) While the cancer risk is the most talked-about "thyroid issue," a more common practical concern involves how GLP-1s affect those already taking medication for an underactive thyroid, such as levothyroxine
Sources [1]Mosqueira A et al
The lawsuit also disputes that the drugs are clinically interchangeable given that they're different molecules despite both being within the broader GLP-1 class
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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